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Breast Cancer Co-amplifications

The amplifications of chromosomes 8 and 11 in breast cancer co-occur. An inspection of these loci with Chromoscope shows that the amplifications are often connected by inter-chromosomal translocations, implicating the derivative chromosome 8/11 as an early event in their formation.1 The segments of loss-of-heterozygosity (LOH) adjacent to the amplicon loci are consistent with this model of amplicon origin. The visualization highlights commonalities in features of the amplicons across 23 samples, as featured in a recent study on the origin of these amplicons.2

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You can view the selected 23 cancer genomes in this Chromoscope configuration:

https://chromoscope.bio/app/?showSamples=true&external=https://somatic-browser-test.s3.amazonaws.com/coamps/configs/coamps.all.config.withnotes.json

  1. Głodzik, D. et al. Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers. Annals of Oncology, 29(11), 2223-2231 (2018).↩
  2. Lee, J. J. K., Jung, Y. L., et al. ERα-associated translocations underlie oncogene amplifications in breast cancer. Nature, 1-9 (2023).↩